Browsing by Author "Rowbotham, D. J."

Now showing items 1-7 of 7

    • Article  

      Antinociceptive effects of the bifunctional opioid UFP-505 

      Dietis, Nikolas; Niwa, H.; Ruggieri, V.; Filaferro, M.; Novi, C.; Guerrini, R.; Calo, G.; Rowbotham, D. J.; Vitale, G.; Lambert, D. G. (2011)
    • Article  

      Characterization of the bifunctional opioid UFP505 

      Tose, R.; Dietis, Nikolas; McDonald, J.; Guerrini, R.; Calo, G.; Salvadori, S.; Rowbotham, D. J.; Lambert, D. G. (2010)
      Morphine is a gold standard analgesic acting at μ-opioid receptors (MOP) with analgesia accompanied by side-effects, for example, tolerance. If δ-opioid receptors (DOP) are blocked at the same time that MOP is activated, ...
    • Article  

      Controlling cancer pain: Is morphine the best we can do? 

      Dietis, Nikolas; Rowbotham, D. J.; Lambert, D. G. (2011)
      Despite the existence of a family of 3 classical and one non-classical opioid receptor, morphine, acting at the MOP (μ) receptor remains the gold standard for use in cancer pain. The main thrust of opioid development has ...
    • Article  

      In vitro and in vivo characterization of the bifunctional μ and δ opioid receptor ligand UFP-505 

      Dietis, Nikolas; Niwa, H.; Tose, R.; McDonald, J.; Ruggieri, V.; Filaferro, M.; Vitale, G.; Micheli, L.; Ghelardini, C.; Salvadori, S.; Calo, G.; Guerrini, R.; Rowbotham, D. J.; Lambert, D. G. (2018)
      Background and Purpose Targeting more than one opioid receptor type simultaneously may have analgesic advantages in reducing side-effects. We have evaluated the mixed μ opioid receptor agonist/ δ opioid receptor antagonist ...
    • Article  

      Opioid receptor subtypes: Fact or artifact? 

      Dietis, Nikolas; Rowbotham, D. J.; Lambert, D. G. (2011)
      There is a vast amount of pharmacological evidence favouring the existence of multiple subtypes of opioid receptors. In addition to the primary classification of (mu: MOP), δ (delta: DOP), κ (kappa: KOP) receptors, and the ...
    • Article  

      Pharmacological characterization of the bifunctional opioid ligand H-Dmt-Tic-Gly-NH-Bzl (UFP-505) 

      Dietis, Nikolas; McDonald, J.; Molinari, S.; Calo, G.; Guerrini, R.; Rowbotham, D. J.; Lambert, D. G. (2012)
      BackgroundWhile producing good-quality analgesia,-opioid (MOP) receptor activation produces a number of side-effects including tolerance. Simultaneous blockade of δ-opioid (DOP) receptors has been shown to reduce tolerance ...
    • Article  

      Simultaneous targeting of multiple opioid receptors: A strategy to improve side-effect profile 

      Dietis, Nikolas; Guerrini, R.; Calo, G.; Salvadori, S.; Rowbotham, D. J.; Lambert, D. G. (2009)
      Opioid receptors are currently classified as (mu: mOP), δ (delta: dOP), κ (kappa: kOP) with a fourth related non-classical opioid receptor for nociceptin/orphainin FQ, NOP. Morphine is the current gold standard analgesic ...